IngentaConnect Lipid microdomains are involved in neurospecific binding and inte...

Authors: Herreros J.^{1, 2}; Schiavo G.^{1, *}

Source: International Journal of Medical Microbiology, Volume 291, Numbers 6-7, February 2002 , pp. 447-453(7)

Abstract:

The neuroparalytic syndromes of tetanus and botulism are caused by tetanus and botulinum neurotoxins, which are produced by bacteria of the genus Clostridia. These neurotoxins are structurally organised in three-domains endowed with different functions: specific interaction with the neuronal surface, membrane translocation and specific cleavage of three key components of the neurotransmitter release apparatus. Despite an identical intracellular activity, tetanus and botulinum neurotoxins are characterised by a differential intraneuronal trafficking, which is likely to be responsible for the different symptoms observed in clinical tetanus and botulism. This review aims to highlight recent discoveries on the recruitment of clostridial neurotoxins (CNTs) to the surface of neurons and neuronally-differentiated cell lines and to discuss their relevance for the internalisation and sorting of these neurotoxins.

Keywords: Tetanus neurotoxin; botulinum neurotoxins; lipid rafts; cholesterol; glycosylphosphatidylinositol-anchored proteins

Language: English

Document Type: Research article

DOI: 10.1078/1438-4221-00152

Affiliations: 1: Molecular Neuropathobiology Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom 2: Present address: J. Herreros, Department of Biological Sciences, Imperial College of Science, Technology & Medicine, Exhibition Road, London, SW7 2AY United Kingdom, Phone: +44 20 7589 5111, ext. 55206, Fax: +44 20 7594 5207, j.herreros@ic.ac.uk *

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$30.00 plus tax Refund Policy

Lipid microdomains are involved in neurospecific binding and internalisation of clostridial neurotoxins