Skip to main content

The reaction of the subependymal layer of lateral brain ventricles to striatal ibotenic acid lesions in a long-term study

Buy Article:

$28.45 plus tax (Refund Policy)


The proliferative activity in the subependymal layer of lateral brain ventricles in adulthood is known. We were interested in the reaction of this layer to ibotenic acid lesions, which simulate neurodegenerative processes in Huntington's disease. Animals with a unilateral ibotenic acid lesion were compared with sham-lesioned animals and control animals with intact brains at 5 and 13 weeks after surgery. Five weeks after surgery, increased proliferation was found in most GFAP-positive astrocytes and to a lesser extent in CNPase-positive oligodendrocytes in comparison with controls. Interestingly, a slight increase in proliferation was found as well in the contralateral non-lesioned hemispheres. Moderate elevation of cell proliferation was found after induction of sham-lesions as well. The intensity of the reaction in the subependymal layer decreased in the following 8 weeks. Only a few scattered cells that originated from the subependymal layer had migrated over a short distance to adjacent brain tissue. We conclude that the reaction of the subependymal layer is (a) non-specific, as it is a response to any type of lesion, and (b) slowly decreases in time.

Keywords: excitotoxic lesion; gliogenesis; proliferation; subependymal layer

Document Type: Original Article


Affiliations: 1: Department of Histology and Embryology, Charles University in Prague, Faculty of Medicine in Hradec Králové, Hradec Králové, Czech Republic 2: Institute of Physiology, Academy of Sciences, Prague, Czech Republic 3: Department of Radiobiology and Immunology, Purkyně Military Medical Academy, Hradec Králové, Czech Republic

Publication date: 2002-12-01

  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more