Skip to main content

RuMast cell infiltration in the wall of varicose veinsbrik

The full text article is temporarily unavailable.

We apologise for the inconvenience. Please try again later.



Varicose veins of the lower extremities are abnormally dilated, tortuous and elongated. The exact cause of vein dilatation has still not been established. Mast cells produce, store and release various types of vasoactive compounds (histamine, tryptase, prostaglandins, leukotrienes, and cytokines). Histamine enhances local vasopermeability and smooth muscle cell proliferation, leading to thickening of the intima. Tryptase can contribute to local vascular injury and subsequent weakness of the vascular wall causing varix formation. The aim of the present study was the comparison of mast cell infiltration in the wall of varicose and non-varicose veins. The mean mast cell density in the wall of varicose veins was 0.86 mast cell per mm2 and in healthy non-dilated vein walls, density was 1.23 mast cell per mm2. This difference was not statistically significant, therefore we could not confirm our hypothesis. Nevertheless, we suggest that mast cells could play an important role in the development of varices and the factor released by the mast cells should be further examined.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: infiltration; mast cell; varicose; veins

Document Type: Original Article

Affiliations: 1: Institute of Anatomy, Bratislava, Slovak Republic 2: Institute of Histology and Embryology, Bratislava, Slovak Republic 3: First Surgical Clinic, Bratislava, Slovak Republic 4: Institute of Forensic Medicine, Bratislava, Slovak Republic

Publication date: 01 December 2002

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more