IngentaConnect Experimental cadmium poisoning in sheep

Authors: Stoev S.D.¹; Grozeva N.¹; Simeonov R.¹; Borisov I.²; Hubenov H.²; Nikolov Y.³; Tsaneva M.⁴; Lazarova S.⁵

Source: Experimental and Toxicologic Pathology, Volume 55, Number 4, November 2003 , pp. 309-314(6)

Abstract:

Pathomorphological investigations of internal organs were made in sheep given sublethal doses of cadmium. Early histological damages in kidneys were established by renal biopsy in some experimental animals. The main histological changes were characterized by granular degeneration in proximal tubules and glomerular endothelial proliferation in kidneys, granular degeneration in hepatocytes, pericapillary oedema and activation of capillary endothelium and Kupffer cells in liver, oedematous and degenerative changes in cerebrum and in the region of Purkinje cells of cerebellum, hyperplasia and proliferation of alveolar epithelium and perivascular or peribronchial mononuclear cell infiltration in lung, and degenerative changes in the medulla and zona glomerulosa of adrenal glands.

Document Type: Research article

DOI: 10.1078/0940-2993-00333

Affiliations: 1: Department of General and clinical pathology, Trakia University, Stara Zagora, Bulgaria 2: Department of Surgery, Trakia University, Stara Zagora, Bulgaria 3: Department of Internal diseases in Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria 4: Department of Pathology in Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria 5: Institute of Experimental Pathology and Parasitology, Bulgarian Academy of Science, Sofia, Bulgaria

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