The effect of osmolality changes on gastric mucosal endogenous prostacyclin levels in drug-induced experimental ulcer model of rat

Authors: Gharzouli K.¹; Balint G.A.²; Galfi M.³; Rimanoczy A.²; Juhasz A.²

Source: Experimental and Toxicologic Pathology, Volume 53, Number 5, October 2001 , pp. 409-411(3)

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Abstract:

Osmolality changes evoked with intragastric administration of natural honey or mannitol, significantly decreased the gastric ulceration of rats induced by indomethacin. Together with this effect, a parallel increase was detectable in the mucosal level of endogenous prostacyclin. Although many processes may be involved in this phenomenon, the authors explain their data with a stimulating effect on gastric mucosal microcirculation due to osmolality changes.

Keywords: Indomethacin; natural honey; mannitol; prostacyclin; gastric ulceration

Language: English

Document Type: Original article

DOI: http://dx.doi.org/10.1078/0940-2993-00208

Affiliations: 1: Department of Biologie, Faculte des Sciences, Universite Ferhat Abbas, Setif; Algerie 2: Laboratory of Clinical Pharmacology, Department of Psychiatry, New Clinics, University of Szeged, Medical Faculty, Szeged; Hungary 3: Department of Biology, Juhasz Gyula Teachers' Training College, University of Szeged, Szeged; Hungary

Publication date: 2001-10-01