8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells
Authors: Rong H.1; Boterberg T.2; Maubach J.1; Stove C.2; Depypere H.3; Van Slambrouck S.1; Serreyn R.3; De Keukeleire D.1; Mareel M.2; Bracke M.2
Source: European Journal of Cell Biology, Volume 80, Number 9, September 2001 , pp. 580-585(6)
Publisher: Urban & Fischer
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Abstract:
The E-cadherin/catenin complex is a powerful invasion suppressor in epithelial cells. It is expressed in the human MCF-7 breast cancer cell line family, but functionally defective in the invasive MCF-7/6 variant. Previous experiments have shown that IGF-I, tamoxifen, retinoic acid and tangeretin are able to upregulate the function of this complex in MCF-7/6 cells. We investigated the effect of 8-prenylnaringenin (8-PN), the phytoestrogen present in hops and beer, on aggregation, growth and invasion in MCF-7/6 cells. 8-PN was found to stimulate E-cadherin-dependent aggregation and growth of MCF-7/6 cells in suspension. These effects could be inhibited by the pure anti-estrogen ICI 182,780. 8-PN did not affect invasion of MCF-7/6 cells in the chick heart assay in vitro. In all these aspects 8-PN mimics the effects of 17
-estradiol on MCF-7/6 cells.
Keywords: 8-Prenylnaringenin; E-cadherin/catenin; MCF-7; phytoestrogens
Language: English
Document Type: Original article
DOI: 10.1078/0171-9335-00190
Affiliations: 1: Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, University Gent, Gent/Belgium 2: Laboratory of Experimental Cancerology, Department of Radiotherapy, Nuclear Medicine and Experimental Cancerology, University Gent, Gent/Belgium 3: Department of Gynaecological Oncology, University Hospital Gent, Gent/Belgium
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