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Fine Structural Analysis of Laser Induced Tissue Alterations in the Central Nervous System and in Brain Tumors

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Laser-induced thermotherapy (LITT) is a minimally invasive approach for the treatment of brain tumors especially in poorly accessible regions. Its clinical applicability with tumor cell destruction under on-line monitoring by magnetic resonance imaging (MRI) has been shown in several studies. This review describes the typical histological alterations following interstitial laser irradiation of the brain and of brain tumors with a specific focus on the fine structural changes of different tissue and cell types and their subcellular components in the central nervous system.

Keywords: Cell Membrane; Histology; Laser; Tumor

Document Type: Original Article


Affiliations: 1: Brigham and Women's Hospital, Cardiovascular Division, Harvard Medical School, Boston, U.S.A., and University of Leipzig, Heart Center, Department of Cardiology, Germany 2: University of Leipzig, Department of Neuropathology, Leipzig, Germany

Publication date: July 1, 2002


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