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Free Content Effects of Cadmium Bioavailability on the Cytoplasmic Distribution of Cadmium in Neanthes Arenaceodentata

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The cytosolic distribution of Cd in the polychaete Neanthes arenaceodentata was examined following 11 weeks of exposure to concentrations of free cadmium ion activities ({Cd2+}) ranging from 10−8 to 10−6.5 M. Dose dependent changes in the accumulation of Cd in different cytosolic ligand pools were determined both radiometrically and by inductively coupled plasma mass spectroscopy. Close agreement was observed between the two sets of data and distinct changes in the relative distribution of cytosolic Cd were noted with increasing external concentrations of metal. At 10−8 M {Cd2+}, cytosolic Cd was largely associated with high molecular weight ligands (50,000–>200,000 Da) with limited metal binding capacity and with a metallothionein-like ligand pool (10,000–20,000 Da). No further accumulation of metal was observed in the high molecular weight ligand pool upon increasing the external {Cd2+} to 10−7 M. However, there was increased accumulation of Cd in the metallothionein-like ligand pool which appeared to reflect induction of the protein and a marked increase in Cd was also observed in a very low molecular weight ligand pool with an apparent molecular weight of <5,000 Da. Increasing the external {Cd2+) to 10−6.5 M caused the progressive accumulation of Cd in both of these ligand pools. The potential of using these dose dependent changes in the cytosolic distribution of Cd in Neanthes as a subcellular indicator for Cd induced stress is discussed.

Document Type: Research Article

Publication date: March 1, 1991

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