Potential new anti-cancer drugs from marine organisms collected at Enewetak Atoll
Authors: Allen, T. M.; Sharma, A.; Dubin, R. E.
Source: Bulletin of Marine Science, Volume 38, Number 1, January 1986 , pp. 4-8(5)
Abstract:Samples of 137 species of marine invertebrates were collected from several different environments at Enewetak Atoll and extracts of the samples were screened for their ability to inhibit the growth of L1210 mouse leukemia cells in culture. Thirty-five species were identified as having substantial activity against L1210 cancer cells. These samples were recollected along with 10 previously uncollected samples. Aqueous and ethanolic extracts of 33 of the recollected organisms were screened for their ability to prolong the survival of mice bearing P388 leukemia. Extracts of 14 species were capable of prolonging the mean survival time of mice by 20% or greater as compared to untreated controls. These species are being studied further in an effort to identify the pharmacologically active compounds.
Document Type: Research Article
Publication date: January 1986
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