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Free Content Potential new anti-cancer drugs from marine organisms collected at Enewetak Atoll

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Abstract:

Samples of 137 species of marine invertebrates were collected from several different environments at Enewetak Atoll and extracts of the samples were screened for their ability to inhibit the growth of L1210 mouse leukemia cells in culture. Thirty-five species were identified as having substantial activity against L1210 cancer cells. These samples were recollected along with 10 previously uncollected samples. Aqueous and ethanolic extracts of 33 of the recollected organisms were screened for their ability to prolong the survival of mice bearing P388 leukemia. Extracts of 14 species were capable of prolonging the mean survival time of mice by 20% or greater as compared to untreated controls. These species are being studied further in an effort to identify the pharmacologically active compounds.

Document Type: Research Article

Publication date: 1986-01-01

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  • The Bulletin of Marine Science is dedicated to the dissemination of high quality research from the world's oceans. All aspects of marine science are treated by the Bulletin of Marine Science, including papers in marine biology, biological oceanography, fisheries, marine affairs, applied marine physics, marine geology and geophysics, marine and atmospheric chemistry, and meteorology and physical oceanography.
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