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Reducing the number of animals used in behavioural genetic experiments using chromosome substitution strains

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Abstract:

Chromosome substitution strains (also called consomic lines or strains) are strains in which a single, full-length chromosome from one inbred strain — the donor strain — has been transferred onto the genetic background of a second inbred strain — the host strain. Based on the results obtained from behavioural tests with the two parental strains, the minimum number of animals from each of the host and consomic strains that are required for a successful behavioural genetic analysis can be estimated. Correct application of statistical knowledge can lead to a further reduction in the number of animals used in behavioural genetic experiments using chromosome substitution strains.

Keywords: ANIMAL WELFARE; BEHAVIOURAL GENETICS; CHROMOSOME SUBSTITUTION STRAIN; MICE; QTL; REDUCTION

Document Type: Research Article

Publication date: 2006-02-01

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