Authors: Panelli, Simona¹; Strozzi, Francesco¹; Capoferri, Rossana²; Barbieri, Ilaria³; Martinelli, Nicola³; Capucci, Lorenzo³; Lombardi, Guerino³; Williams, John¹

Source: Journal of Toxicology and Environmental Health Part A, Volume 74, Numbers 2-4, January 2011 , pp. 96-102(7)

Publisher: Taylor and Francis Ltd

Abstract:

Bovine amyloidotic spongiform encephalopathy (BASE) is one of the recently discovered atypical forms of BSE, which is transmissible to primates, and may be the bovine equivalent of sporadic Creutzfeldt-Jacob disease (CJD) in humans. Although it is transmissible, it is unknown whether BASE is acquired through infection or arises spontaneously. In the present study, the gene expression of white blood cells (WBCs) from 5 cattle at 1 yr after oral BASE challenge was compared with negative controls using a custom microarray containing 43,768 unique gene probes. In total, 56 genes were found to be differentially expressed between BASE and control animals with a log fold change of 2 or greater. Of these, 39 were upregulated in BASE animals, while 17 were downregulated. The majority of these genes are related to immune function. In particular, BASE animals appeared to have significantly modified expression of genes linked to T- and B-cell development and activation, and to inflammatory responses. The potential impacts of these gene expression changes are described.

Document Type: Research article

DOI: http://dx.doi.org/10.1080/15287394.2011.529059

Affiliations: 1: IDRA-LAB, Parco Tecnologico Padano, Lodi 2: IDRA-LAB, Istituto Sperimentale Italiano “L. Spallanzani,” Lodi, Italy 3: IIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Brescia

Publication date: 2011-01-01

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