Non-Neoplastic and Neoplastic Pleural Endpoints Following Fiber Exposure
Exposure to asbestos fibers is associated with non-neoplastic pleural diseases including plaques, fibrosis, and benign effusions, as well as with diffuse malignant pleural mesothelioma. Translocation and retention of fibers are fundamental processes in understanding the interactions
between the dose and dimensions of fibers retained at this anatomic site and the subsequent pathological reactions. The initial interaction of fibers with target cells in the pleura has been studied in cellular models in vitro and in experimental studies in vivo. The proposed biological mechanisms
responsible for non-neoplastic and neoplastic pleural diseases and the physical and chemical properties of asbestos fibers relevant to these mechanisms are critically reviewed. Understanding mechanisms of asbestos fiber toxicity may help us anticipate the problems from future exposures both
to asbestos and to novel fibrous materials such as nanotubes. Gaps in our understanding have been outlined as guides for future research.
Document Type: Research Article
Affiliations: 1: University of California, San Francisco, San Francisco, California, USA 2: GlaxoSmithKline, Research Triangle Park, North Carolina, USA 3: Center for Asbestos Related Disease, Libby, Montana, USA 4: Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USA
Publication date: 01 January 2011
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