Acute Respiratory Syndrome After Inhalation of Waterproofing Sprays: A Posteriori Exposure-Response Assessment in 102 Cases

Authors: Vernez, David¹; Bruzzi, Raffaella¹; Kupferschmidt, Hugo²; De-Batz, Alice¹; Droz, Pierre¹; Lazor, Romain³

Source: Journal of Occupational and Environmental Hygiene, Volume 3, Number 5, May 2006 , pp. 250-261(12)

Publisher: Taylor and Francis Ltd

Abstract:

Waterproofing agents are widely used to protect leather and textiles in both domestic and occupational activities. An outbreak of acute respiratory syndrome following exposure to waterproofing sprays occurred during the winter 2002-2003 in Switzerland. About 180 cases were reported by the Swiss Toxicological Information Centre between October 2002 and March 2003, whereas fewer than 10 cases per year had been recorded previously. The reported cases involved three brands of sprays containing a common waterproofing mixture, that had undergone a formulation change in the months preceding the outbreak. A retrospective analysis was undertaken in collaboration with the Swiss Toxicological Information Centre and the Swiss Registries for Interstitial and Orphan Lung Diseases to clarify the circumstances and possible causes of the observed health effects. Individual exposure data were generated with questionnaires and experimental emission measurements. The collected data was used to conduct numeric simulation for 102 cases of exposure. A classical two-zone model was used to assess the aerosol dispersion in the near- and far-field during spraying. The resulting assessed dose and exposure levels obtained were spread on large scales, of several orders of magnitude. No dose-response relationship was found between exposure indicators and health effects indicators (perceived severity and clinical indicators). Weak relationships were found between unspecific inflammatory response indicators (leukocytes, C-reactive protein) and the maximal exposure concentration. The results obtained disclose a high interindividual response variability and suggest that some indirect mechanism(s) predominates in the respiratory disease occurrence. Furthermore, no threshold could be found to define a safe level of exposure. These findings suggest that the improvement of environmental exposure conditions during spraying alone does not constitute a sufficient measure to prevent future outbreaks of waterproofing spray toxicity. More efficient preventive measures are needed prior to the marketing and distribution of new waterproofing agents.

Keywords: airborne particles; exposure assessment; fluororesins; respiratory diseases; waterproofing spray

Document Type: Research article

DOI: http://dx.doi.org/10.1080/15459620600628845

Affiliations: 1: Institute of Occupational Health Sciences, Lausanne, Switzerland 2: Swiss Toxicological Information Centre, Zurich, Switzerland 3: Pulmonary Division, University Hospital, Bern, Switzerland, for the Swiss Group for Interstitial and Orphan Lung Diseases

Publication date: 2006-05-01

Related content

• In this: publication
• By this: publisher
• By this author: Vernez, David ;  Bruzzi, Raffaella ;  Kupferschmidt, Hugo ;  De-Batz, Alice ;  Droz, Pierre ;  Lazor, Romain

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers