Authors: Petersen, H.¹; Biereichel, A.²; Burseg, K.²; Simat, T. J.³; Steinhart, H.²

Source: Food Additives and Contaminants, Volume 25, Number 7, July 2008 , pp. 911-920(10)

Publisher: Taylor and Francis Ltd

Abstract:

Bisphenol A diglycidyl ether (BADGE) is widely used as a monomer for coatings and adhesives for food-contact applications. Previous publications indicate that, after migration from packaging into foodstuffs, BADGE undergoes various reactions with unidentified food components. In order to elucidate the fate of BADGE, losses were determined after incubation with different foodstuffs and food components. Food proteins were identified as the main reaction partner with BADGE. Adduct formation was found with nucleophilic side-chains of amino acids. In vitro, cysteine exhibited significant activity. The previously reported occurrence of methylthio-derivatives of BADGE in foodstuffs was shown to originate from the reaction of BADGE with methionine. BADGE-methylthio derivatives can, therefore, be used as marker substances in foodstuffs for protein reactions with BADGE. The reported results offer a new viewpoint on the evaluation of BADGE migration. The hydrolysis and hydrochlorination derivatives subject to European legislation make up only a fraction of the totally migrated BADGE, and a further concern is that the toxic or allergenic potential of the protein adducts are unknown.

Keywords: bisphenol A diglycidyl ether (BADGE); migration; food packaging; canned food; protein adducts

Document Type: Research article

DOI: http://dx.doi.org/10.1080/02652030701837399

Affiliations: 1: Central Institute of Medical Service German Bundeswehr, Kiel, Germany 2: Institute of Biochemistry and Food Chemistry, University of Hamburg, Hamburg, Germany 3: Technical University of Dresden, Dresden, Germany

Publication date: 2008-07-01

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