IngentaConnect Oestrogenicity of paper and cardboard extracts used as food conta...

Authors: Lopez-Espinosa, M. -J.¹; Granada, A.¹; Araque, P.¹; Molina-Molina, J. -M.¹; Puertollano, M. -C.¹; Rivas, A.²; Fernández, M.¹; Cerrillo, I.¹; Olea-Serrano, M. -F.²; López, C.³; Olea, N.¹

Source: Food Additives and Contaminants, Volume 24, Number 1, January 2007 , pp. 95-102(8)

Publisher: Taylor and Francis Ltd

Abstract:

Bisphenol-A (BPA), dibutyl phthalate (DBP), and di-2-ethylhexyl phthalate (DEHP), which are common chemical residues in food-packaging materials, were investigated in paper and cardboard containers used for take-away food. The oestrogenicity of aqueous extracts was tested in E-Screen bioassay and analysis carried out by high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC/MS). Oestrogenicity was demonstrated in 90% of extracts (geometric mean [GM] = 11.97 pM oestradiol equivalents g-1). DEHP, DBP, and BPA (GM = 341.74, 37.59, and 2.38 ng g-1 of material) were present in 77.50, 67.50, and 47.50% of samples, respectively. In bivariate analyses, no significant association was found between the levels of these chemicals and oestrogenicity in cardboard/paper extracts. A close-to-significant association was found between oestrogenicity and DBP (β = 1.25; p = 0.06) in paper extracts, which reached statistical significance in multivariate analysis (β = 1.61; p = 0.03). Paper and cardboard used in food packaging may contribute to the inadvertent exposure of consumers to endocrine-disrupting chemicals.

Keywords: Paper and cardboard; phthalates; bisphenol-A; oestrogenicity

Document Type: Research article

DOI: 10.1080/02652030600936375

Affiliations: 1: Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, E-18071 Granada, Spain 2: Department of Nutrition and Food Sciences, 3: Department of Physical Chemistry, University of Granada, E-18071 Granada, Spain

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Oestrogenicity of paper and cardboard extracts used as food containers