Residue formation of fumonisin B1 in porcine tissues

Authors: Meyer K.; Mohr K.; Bauer J.; Horn P.; Kovács M.

Source: Food Additives and Contaminants, Volume 20, Number 7, July 2003 , pp. 639-647(9)

Publisher: Taylor and Francis Ltd

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Abstract:

The residues derived from the uptake of fumonisin B1, a toxic metabolite of Fusarium verticillioides frequently occurring in corn and corn products, were determined in growing pigs. After oral administration of 100 mg FB₁/animal/day for 5-11 days, serum, bile, lung, liver, kidney, brain, spleen, pancreas, heart, muscle, eye, and fat samples were collected immediately and analysed by LC-MS. The highest values were measured in kidney (833 ± 1329

g kg^-1, mean ± SD), liver (231 ± 163

g kg^-1), lung (170 ± 311

g kg^-1) and spleen (854 ± 2212

g kg^-1). Muscle contained 26 ± 41

g kg^-1, while in fat only 2 ± 3

g kg^-1 were traceable. Despite the potential accumulation over extended feeding periods as well as the large variations in the residue formation of FB₁, a carry-over in edible tissues from swine was considered not to be of toxicological relevance.

Keywords: fumonisin; pig; residues; LC-MS; consumer health; mycotoxin

Document Type: Research article

DOI: 10.1080/0265203031000119043

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