This research evaluates the influence of different designs of in car guidance information on visual explorations and subjective preferences, taking into account the drivers characteristics. The results showed that each guidance information representation factors—the number of exit roads, the presence or absence of a landmark and the types of intersections— has a significant influence on the mean maximum duration of glances. Moreover, below a raised threshold of complexity, the number of glances remains stable and independent of the quantity of information presented, whereas passing this threshold demands extra glances from the driver. Lastly, the majority of drivers prefers the complex guidance designs, enabling them to form an unambiguous mental representation. Some effects of the age and gender factors are found. The overall results are interpreted in the framework of the perceptual processes and visuo-spatial working memory models. In conclusion, psycho-ergonomics recommendations are proposed.