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Genomic selection

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Abstract:

Computer simulation was used to examine the relationship between the number of loci included in the model and the accuracy of whole-genome methods for genetic evaluation. Random-regression BLUP (RR-BLUP) and Bayesian inference (Bayes-B) were compared with BLUP based on trait phenotypes and pedigree (TP-BLUP), where the genomic information consisted of genotypes at 110 or 2010 unlinked SNP loci. Of these loci, 10 were the actual trait loci. Accuracies for RR-BLUP were much higher than for TP-BLUP with 110 loci, but they were closer to TP-BLUP with 2010 loci. Accuracies with Bayes-B were close to 1 with 110 or with 2010 loci. Results for Bayes-B were also examined with a range of 3000 to 60 000 markers in linkage disequilibrium on 30 chromosomes. Increasing the number of markers did not lower the accuracy of Bayes-B. Thus, Bayes-B seems to be well suited for whole-genome analyses with large numbers of loci. This may not be the case for RR-BLUP.

Keywords: BLUP; Bayesian inference; computer simulation; genetic evaluation; marker-assisted selection

Document Type: Research Article

DOI: http://dx.doi.org/10.1080/09064700801959395

Affiliations: 1: Department of Animal Science, Iowa State University, Ames, IA, USA,Center for Integrated Animal Genomics, Iowa State University, Ames, IA, USA 2: Department of Animal Science, Iowa State University, Ames, IA, USA 3: Applied Genetics Network, Davos, Switzerland 4: Pioneer Hi-Bred, a DuPont Business, Johnston, IA, USA

Publication date: December 1, 2007

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