Antifungal Diterpenoids and Flavonoids from Ballota inaequidens

Authors: Çito gbreve lu, Gülçin¹; Sever, Betül¹; Antus, Sándor²; Baitz-Gács, Eszter³; Altanlar, Nurten⁴

Source: Pharmaceutical Biology (Formerly International Journal of Pharmacognosy), Volume 42, Number 8, December 2004 , pp. 659-663(5)

Publisher: Taylor and Francis Ltd

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Abstract:

Two diterpenoids (hispanolone 1, ballonigrine 2) and six flavonoids (5-hydroxy-3,7,4'-trimethoxyflavone 3, retusin 4, 5-hydroxy-7,4'-dimethoxyflavone 5, pachypodol 6, 5-hydroxy-3,6,7,4'-tetramethoxyflavone 7, 5-hydroxy-7,3',4'-trimethoxyflavone 8) have been isolated from the aerial parts of Ballota inaequidens Hub.-Mor. & Patzak. Among them, 7 has not been reported previously in the genus Ballota . The antibacterial and antifungal activities of 1–4, 6, and 8 were tested against Bacillus subtilis , Staphylococcus aureus , Escherichia coli , Pseudomonas aeruginosa , Candida albicans , and Candida crusei .

Keywords: Antifungal activity; Ballota inaequidens; ballonigrine; hispanolone; pachypodol; retusin; 5-hydroxy- 3,7,4 prime -trimethoxyflavone; 5-hydroxy-7,4 prime -dimethoxyflavone; 5-hydroxy-3,6,7,4 prime -tetramethoxyflavone; 5-hydroxy-7,3,4 prime -trimethoxyflavone

Document Type: Research article

DOI: http://dx.doi.org/10.1080/13880200490902626

Affiliations: 1: Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, 06100, Ankara, Turkey 2: Department of Organic Chemistry, University of Debrecen, H-4010, Debrecen, Hungary 3: Institute of Chemistry, CRC Hungarian Academy of Sciences, H-1525, Budapest, Hungary 4: Department of Microbiology, Faculty of Pharmacy, Ankara University, 06100, Ankara, Turkey

Publication date: 2004-12-01