Comparison of point-of-care analysis using Coaguchek XS and standard laboratory-measured prothrombin time in dogs
AIMS: The Coaguchek XS is a hand-held coagulation monitor, which is widely available for human testing, and could have applications for canine samples. The aim of this study was a preliminary evaluation of the suitability of this point-of-care device to determine prothrombin time (PT)
in dogs by measuring the clinical agreement between the results obtained using the device and standard laboratory testing.
METHODS: The PT in 24 samples from 13 dogs with suspected coagulopathy and 40 samples from 40 healthy dogs was determined concurrently using the point-of-care device and standard laboratory analysis. The clinical agreement between methods was assessed using Bland-Altman analysis and error grid analysis.
RESULTS: Four of the paired samples were not suitable for analysis. The point-of-care device showed a 1.29 fold positive systematic bias which, when corrected for, gave excellent clinical agreement. Differences in the results obtained would have influenced clinical decision making in only 3 of 60 (5.0%) samples where the point-of-care result suggested a more prolonged PT than laboratory testing. A measurement error occurred in two point-of-care samples which may have been due to the combination of severe anaemia and severely prolonged PT.
CONCLUSIONS AND CLINICAL RELEVANCE: The point-of-care device can be used in dogs and would provide rapid analysis of PT to aid clinical decision making in dogs with suspected rodenticide toxicity. Development of a device-specific reference range for dogs would improve its value.
METHODS: The PT in 24 samples from 13 dogs with suspected coagulopathy and 40 samples from 40 healthy dogs was determined concurrently using the point-of-care device and standard laboratory analysis. The clinical agreement between methods was assessed using Bland-Altman analysis and error grid analysis.
RESULTS: Four of the paired samples were not suitable for analysis. The point-of-care device showed a 1.29 fold positive systematic bias which, when corrected for, gave excellent clinical agreement. Differences in the results obtained would have influenced clinical decision making in only 3 of 60 (5.0%) samples where the point-of-care result suggested a more prolonged PT than laboratory testing. A measurement error occurred in two point-of-care samples which may have been due to the combination of severe anaemia and severely prolonged PT.
CONCLUSIONS AND CLINICAL RELEVANCE: The point-of-care device can be used in dogs and would provide rapid analysis of PT to aid clinical decision making in dogs with suspected rodenticide toxicity. Development of a device-specific reference range for dogs would improve its value.
Keywords: Coaguchek XS; dog; method comparison; point-of-care; prothrombin time
Document Type: Research Article
Affiliations: 1: Dunedin South Veterinary Clinic, 44 Rankeilor StDunedin, New Zealand 2: Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand
Publication date: 01 January 2013
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