Observations on the prevention of cleft palate in dogs by folic acid and potential relevance to humans

Authors: Elwood, JM; Colquhoun, TA

Source: New Zealand Veterinary Journal, Volume 45, Number 6, 1 December 1997 , pp. 254-256(3)

Publisher: Taylor and Francis Ltd

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Folic acid has been shown to prevent neural tube defects in humans, but its effects on other defects is unknown. In a consistent breeding programme of Boston terrier dogs started in 1974, folic acid supplementation (5 mg/day) was introduced in 1981. The frequency of cleft palate fell from 9/51 (17.6%) without folic acid to 8/191 (4.2%) after its introduction, giving a reduction of 76% (95% confidence limits 42%-90%, p = 0.003).

Keywords: Congenital disease; Dog; Neurological

Document Type: Short Communication

Publication date: December 1, 1997

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