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Observations on the prevention of cleft palate in dogs by folic acid and potential relevance to humans

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Folic acid has been shown to prevent neural tube defects in humans, but its effects on other defects is unknown. In a consistent breeding programme of Boston terrier dogs started in 1974, folic acid supplementation (5 mg/day) was introduced in 1981. The frequency of cleft palate fell from 9/51 (17.6%) without folic acid to 8/191 (4.2%) after its introduction, giving a reduction of 76% (95% confidence limits 42%-90%, p = 0.003).
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Keywords: Congenital disease; Dog; Neurological

Document Type: Short Communication

Publication date: 1997-12-01

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