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Abstract:



While fully supporting the publication of review articles in our Journal, I find it unfortunate that these cannot be sourced from close to home. Admittedly in some disciplines far distant experts may know best, but surely in this part of the world, with our huge anthelmintic usage, there must be an authority willing and able to produce an article of the kind recently imported from Ireland. Maybe something was lost in translation, for as well as the irritating spelling and typographical errors, there were some factual inaccuracies which need to be corrected. Firstly, oxfendazole is not the active metabolite of albendazole. Both compounds belong to the extended family of benzimidazoles, but albendazole and oxfendazole are distant cousins in contrast with the direct lineage of febantel, fenbendazole and oxfendazole. Secondly, the metabolism of albendazole to the active sulphoxide does not take place in the rumen. Marriner and Began were unable to find sulphoxide in ruminal fluid, when taken directly from treated sheep, or when incubated in the laboratory; they concluded that albendazole is metabolised after absorption…

Keywords: Anthelmintic resistance; Anthelmintics; Livestock; Pharmacology

Document Type: Regular Paper

Publication date: March 1, 1985

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tandf/nzvj/1985/00000033/00000003/art00012
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