One-Pot Multicomponent Michael and Thorpe–Ziegler Reaction of Aryl Methyl Ketones
A regioselective base-promoted Michael and Thorpe–Ziegler reaction between aryl methyl ketones and α,β-unsaturated nitrile was carried out in a single step. Different functional groups in addition to active positions were tolerated under this condition. Results indicated
that the reaction proceeds in a consecutive manner as double Michael, triple Michael, and Thorpe–Ziegler condensation. By applying click chemistry, double Michael adducts were converted to bis-tetrazoles, which have broad applications in coordination and medicinal chemistry.
Keywords: Aryl methyl ketone; Thorpe–Ziegler condensation; tetrazoles; triple Michael reaction
Document Type: Research Article
Affiliations: Institute of Himalayan Bioresource Technology, Palampur, India
Publication date: 01 September 2011
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