FeCl3 · 6H2O-Catalyzed Acceleration of the Acylation of Sodium Azide with N-Acylbenzotriazoles
[image omitted] Catalyzed by ferric chloride hexahydrate (FeCl3 · 6H2O), the acylation of sodium azide with N-acylbenzotriazoles was greatly accelerated in a mixed solvent of acetone and water. Thus, good to excellent yields of a variety of acyl azides were obtained
at room temperature in a short time. Furthermore, because of the complete conversion of N-acylbenzotriazoles and the easy removal of the by-product, purification by column chromatography was no longer required, which made the protocol suitable for large-scale preparation.
Keywords: Acylation; N-acylbenzotriazoles; acyl azides; ferric chloride hexahydrate (FeCl3 · 6H2O); sodium azide
Document Type: Research Article
Affiliations: Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, China
Publication date: 01 January 2011
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