Silica Gel Promotes Cascade Synthesis of 2-(Heteroaryl)acetamide Derivatives from Isocyanides, Dialkylamines, and Heteroarylcarbaldehydes
Addition of an isocyanide to an iminium ion intermediate that forms from the reaction between a heteroarylcarbaldehyde and a secondary amine leads to formation of sterically congested 2-(heteroaryl)acetamide derivatives in the presence of silica gel at room temperature. The structures
of the products were deduced from their 1H NMR, 13C NMR, and infrared spectra and mass spectrometry. ![]()
Keywords: Heteroarylcarbaldehyde; iminium ion; isocyanide; multicomponent reaction; secondary amine; silica gel
Document Type: Research Article
Affiliations: 1: Chemistry Department, Zanjan University, Zanjan, Iran 2: Chemistry Department, Payam Noor University, Zanjan, Iran 3: Chemistry Department, Payam Noor University, Abhar, Zanjan, Iran
Publication date: 19 April 2011
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