Laccase from Basidiomycetous Fungus-Catalyzed Synthesis of Substituted Benzopyranocoumarins via Domino Reaction
[image omitted] The present investigation provides a simple and convenient route to organic synthesis of substituted benzopyranocoumarin, which is important because it is a probable HIV protease inhibitor. The reaction of α,-unsaturated derivatives of coumarins with catechol or 1,4-hydroquinones was catalyzed using laccase in an aqueous medium. Quinones, generated in situ by the oxidation of the corresponding catechol or 1,4-hydroquinones, underwent a domino reaction with chalcones to produce benzopyranocoumarins.
Keywords: Aqueous medium; benzopyranocoumarin; domino reaction; laccase; reusability
Document Type: Research Article
Affiliations: 1: Green Research Laboratory, Department of Chemistry, University of Delhi, Delhi, India 2: Lignocellulose Biotechnology Laboratory, Department of Microbiology, University of Delhi South Campus, Delhi, India
Publication date: 01 January 2011
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