Fast, Solvent-Free, Microwave-Promoted Friedlander Annulation with a Reusable Solid Catalyst
A fast, solvent-free method is described for the synthesis of substituted quinoline derivatives via Friedlander cyclization, employing a reusable solid catalyst (silica-propylsulfonic acid). Although it worked best under microwave irradiation (with generally more than 90% isolated yields in 30 min), the reaction was also feasible under conventional heating (with fair to good yields in about 5 h).
Keywords: Friedlander synthesis; microwaves; quinoline; solid catalyst; solvent-free
Document Type: Research Article
Affiliations: 1: Dipartimento di Scienza e Tecnologia del Farmaco, Universita di Torino, Torino, Italy 2: Dipartimento di Scienza e Tecnologia del Farmaco, Universita di Torino, Torino, Italy,Centro de Quimica Farmaceutica, Ciudad de La Habana, Cuba 3: Dipartimento di Scienze Chimiche e Ambientali, Universita dell'Insubria, Como, Italy
Publication date: 01 January 2010
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