Facile and Versatile Room-Temperature Synthesis of N,N-Disubstituted Cyanoacetamides from Malonic Ester Chloride
A general method for the synthesis of various N,N-disubstituted cyanoacetamides from readily available methyl malonyl chloride and secondary amines, including sterically demanding aliphatic and aromatic amines, is described.
Keywords: Cyanoacetamides; dehydration; malonamides; nitriles
Document Type: Research Article
Affiliations: PLIVA Krakow Pharmaceutical Company, Krakow, Poland
Publication date: 01 January 2009
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