Selective Metallation of 3-Halothiophenes: Practical Methods for the Synthesis of 2-Bromo-3-formylthiophene
Selective lithiation of 3-bromothiophene was accomplished under controlled conditions without formation of undesired thienyllithium compounds. A thienyl Grignard reagent derived from 2-bromo-3-iodothiophene was transformed into 2-bromo-3-formylthiophene in high selectivity by formylation with dimethylformamide (DMF) at optimal reaction temperature.
Keywords: 2-Bromo-3-formylthiophene; 2-bromo-3-iodothiophene; 3-bromothiophene; thienyl Grignard reagent; thienyllithium reagent
Document Type: Research Article
Affiliations: Division of Frontier Materials Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan
Publication date: 01 January 2009
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