Kumada-Corriu Cross Coupling Route to the Anti-Cancer Agent Combretastatin A-4

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A short and efficient synthesis of the anticancer agent combretastatin A-4 was accomplished from inexpensive starting materials using the iron-catalyzed cross-coupling of a Grignard reagent and a bromostilbene as the key step.

Keywords: Anticancer; cross-coupling; iron catalysis; stilbene

Document Type: Research Article

DOI: http://dx.doi.org/10.1080/00397910802238692

Affiliations: Facultad de Ciencias Quimicas, Universidad Autonoma de Chihuahua, Chihuahua, Mexico

Publication date: January 1, 2008

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