Silica-Supported Perchloric Acid (HClO4-SiO2): An Efficient Catalyst for the Preparation of -Amido Carbonyl Compounds Using Multicomponent Reactions
Abstract:A new, one-pot, efficient, three-component condensation of benzaldehyde derivatives, enolizable ketones, acetyl chloride, and acetonitrile or benzonitrile in the presence of silica-supported perchloric acid as an effective catalyst for the synthesis of -amido carbonyl compounds is described. The present methodology offers several advantages, such as good yields, short reaction times, and simple workup procedure.
Document Type: Research Article
Affiliations: Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran
Publication date: 2008-01-01