Click Reaction: Highly Efficient Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

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In this work, condensation reaction of 2-aminobenzamide with various alkyl, aryl, and alicyclic aldehydes or ketones to 2,3-dihydroquinazolin-4(1H)-one derivatives in the presence of a catalytic amount of ammonium chloride in ethanol at room temperature is described. This reaction can be classified as a click chemical synthesis because of its high yields, short reaction times, and green and efficient reaction medium.

Keywords: 2,3-dihydroquinazolin-4(1H)-one; 2-Aminobenzamide; ammonium chloride; click chemistry; green chemistry; quantitative yield

Document Type: Research Article


Affiliations: Department of Chemistry, Shahid Beheshti University, Tehran, Iran

Publication date: January 1, 2008

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