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P2O5-Hexamethyldisiloxane (HMDS): An Efficient System to Induce the Three-Component Reaction of Enolic Systems, Aromatic Aldehydes, and Acetonitrile

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Abstract:

Three-component reaction of an enolizable compound, such as acetophenone, methyl acetoacetate, 4-hydroxycoumarin, 2-naphthol, or 3-hydroxy-2-naphthoic acid; an aromatic aldehyde, and acetonitrile induced by phosphorus pentoxide and hexamethyldisiloxane leads to 2-acetylamino ketones, methyl 3-(acetylamino aryl methyl)-3-oxobutanoates, 3-(acetylamino aryl methyl)-4-hydroxycoumarins, 1-(acetylamino aryl methyl)-2-naphthols, or 4-(acetylamino aryl methyl)-3-hydroxy-2-naphthoic acids in excellent yields.

Keywords: 2-naphthol; 4-hydroxycoumarin; Aryl aldehydes; hexamethyldisiloxane; phosphorus pentoxide; three-component reaction

Document Type: Research Article

DOI: http://dx.doi.org/10.1080/00397910802213778

Affiliations: Department of Chemistry, Islamic Azad University, Yazd Branch, Yazd, Iran

Publication date: January 1, 2008

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