Synthesis of Ureido-Linked Glycosylated Amino Acids from Nα-Fmoc-Asp/Glu-5-oxazolidinones and Their Application to Neoglycopeptide Synthesis
A simple route for the synthesis of ureido-linked glycosylated amino acids has been described. The key step involves the reaction of isocyanates derived from Nα-Fmoc-Asp/Glu-5-oxazolidinones 1 with glycosyl amines followed by hydrolysis. The resulting ureido-linked glycosylated amino acids have been incorporated into peptides. The overall procedure is simple, high-yielding, and involves fewer steps.
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