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Home / Synthetic Communications, Volume 37, Number 14

Synthesis of 3-Heteroaryl-Substituted Tetrahydrofurans from the Baylis-Hillman Adducts of Heteroarylaldehydes by n-Bu3SnH-Mediated 5-exo-trig Vinyl Radical Cyclization

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The synthesis of 3-heteroaryl-substituted tetrahydrofurans from the propargyl derivative of Baylis-Hillman adducts of heteroaryl aldehydes by n-Bu3SnH-mediated 5-exo-trig vinyl radical cyclization in high yield is reported.

Keywords: 5-exo-trig; Baylis-Hillman adduct; n-Bu3SnH; tetrahydrofuran; vinyl radical

Document Type: Research Article

Affiliations: Chemical Sciences and Technology Division, Regional Research Laboratory (CSIR), Thiruvananthapuram, Kerala, India

Publication date: 01 January 2007

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