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Straightforward Synthesis of a Novel Maleimide‐DTPA Bifunctional Chelating Agent

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An extremely easy and multigram scale synthesis of a new maleimide-DTPA derivative is described. This bifunctional chelating agent finds application in bioconjugate chemistry because the maleimido group allows easy labeling of thiol-containing molecules (e.g., proteins, peptides) and the DTPA moiety ensures a strong and stable coordination of metal and radiometal ions such as gadolinium, lutetium, indium, and yttrium.
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Keywords: Bifunctional chelating agent; DTPA; bioconjugate chemistry; labeling; maleimide linker; thiol

Document Type: Research Article

Affiliations: Bracco Imaging Spa, Milano Research Centre, Milano, Italy

Publication date: 01 January 2005

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