Straightforward Synthesis of a Novel Maleimide‐DTPA Bifunctional Chelating Agent
An extremely easy and multigram scale synthesis of a new maleimide-DTPA derivative is described. This bifunctional chelating agent finds application in bioconjugate chemistry because the maleimido group allows easy labeling of thiol-containing molecules (e.g., proteins, peptides) and the DTPA moiety ensures a strong and stable coordination of metal and radiometal ions such as gadolinium, lutetium, indium, and yttrium.
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