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Home / Separation Science and Technology, Volume 46, Number 6

Supercritical Fluid Extraction Coupled with Solvent-Less Spray Collection Mode for Rapid Separation of Indirubin and Tryptanthrin from Folium Isatidis

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Supercritical carbon dioxide modified with acetonitrile and water for the extraction of indirubin and tryptanthrin from Folium Isatidis and the collection of these two bioactive ingredients by a spray mode are presented in this study. Two pumps, one for the addition of the modifier and the other for the transportation of CO2, were used for supercritical fluid extraction (SFE). This is a fast and environmentally-friendly approach for the production of herbal medicine. Compared to conventional solvent extraction, the yield of bioactive indirubin and tryptanthrin by this SFE process was approximately the same, but with a shorter process time and better protection of the environment.

Keywords: folium isatidis; indirubin; supercritical fluid extraction; tryptanthrin

Document Type: Research Article

Affiliations: 1: Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan 2: Department of Radiological Technology, Yuanpei University, Hsinchu, Taiwan 3: Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University, Hsinchu, Taiwan 4: Department of Applied Science, National DongHwa University, Hualien, Taiwan

Publication date: 01 January 2011

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