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Gastrodin, a pharmacologically active constituent, was ultrasonically extracted from gastrodia elata Bl. in the aqueous solution. The effects of six parameters including ethanol-water compositions, extraction time, extraction temperature, particle size, solvent volume, and ultrasonic
power on the extraction yield of gastrodin were investigated. According to the orthogonal design, the optimal extraction conditions was explored as extraction temperature 60°C, extraction time 50 minutes, ultrasonic power 126 W, solvent volume 8 mL · g-1, ethanol-water
compositions 70%, and particle size 10-20 mesh. Though the yield of gastrodin via ultrasonic extraction was about 0.01% lower than that from the reflux extraction, the extraction time of the ultrasonic extraction was greatly shortened. Therefore, ultrasonic extraction has high efficiency and
is proved to be very valuable in the extraction of gastrodin from gastrodia elata Bl.