Divalent Amino Acid Adsorption on Cation Exchange Resin

Authors: Nagai, Hidetada1; Hasegawa, Kazuhiro2

Source: Separation Science and Technology, Volume 44, Number 13, January 2009 , pp. 3075-3087(13)

Publisher: Taylor and Francis Ltd

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Mass transport of divalent amino acids, arginine and histidine, was investigated in an ion exchange system using DIAION SK104, SK1BL, and SK112. Ion exchange equilibrium constants of arginine were 5.0 g/cm3 for SK104 (4 wt% D.V.B.), 25.0 g/cm3 for SK1BL (8 wt% D.V.B.) and 25.0 g/cm3 for SK112 (12 wt% D.V.B.). The ion exchange equilibrium constant of histidine was 8.0 g/cm3 for SK1BL (8 wt% D.V.B.). Resin phase diffusivities of divalent amino acids are measured by batch uptake experiments. Resin phase diffusivities of divalent arginine were decreased from 9.0 × 10-8 cm2/s to 1.6 × 10-8 cm2/s while the D.V.B. content in resin increases from 4 wt% to 12 wt%. Resin phase diffusivity of histidine for 8 wt% D.V.B. resin was 7.0 × 10-8 cm2/s. The steric hindrance model was able to describe measured resin phase diffusivities.

Keywords: Amino acids; intraparticle diffusivity; ion exchange; mass transfer

Document Type: Research Article

DOI: http://dx.doi.org/10.1080/01496390903182248

Affiliations: 1: Ajinomoto, Co., Inc., Production and Technology Administration Center, Kawasaki-ku, Kawasaki-shi, Japan 2: Ajinomoto, Co., Inc., Fermentation & Biotechnology Laboratories, Kawasaki-ku, Kawasaki-shi, Japan

Publication date: January 1, 2009

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