Purification of S-PG05 using Simulated Moving Bed Chromatography
S-PG05 ((15S)-15-methyl-prostaglandin F2α methyl ester) was separated from the epimer R-PG05 and other impurities using SMB, combined with batch chromatography. Based on this technical procedure, 94% pure S-PG05 was obtained. Different column configurations and separation conditions of SMB have been selected. A non-synchronous shift with a “partial extract withdrawal” strategy has been employed, resulting in the saving of desorbent and the increase of the purity of S-PG05.
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Document Type: Research Article
Affiliations: Center of Separation Technology, University of Science and Technology of Liaoning, Anshan, Liaoning, P. R. China
Publication date: 01 May 2009