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Purification of S-PG05 using Simulated Moving Bed Chromatography

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Abstract:

S-PG05 ((15S)-15-methyl-prostaglandin F2α methyl ester) was separated from the epimer R-PG05 and other impurities using SMB, combined with batch chromatography. Based on this technical procedure, 94% pure S-PG05 was obtained. Different column configurations and separation conditions of SMB have been selected. A non-synchronous shift with a “partial extract withdrawal” strategy has been employed, resulting in the saving of desorbent and the increase of the purity of S-PG05.

Keywords: Non-synchronous shift; S-PG05; partial extract withdrawal; prostaglandins; simulated moving bed Chromatography

Document Type: Research Article

DOI: http://dx.doi.org/10.1080/01496390902775448

Affiliations: Center of Separation Technology, University of Science and Technology of Liaoning, Anshan, Liaoning, P. R. China

Publication date: May 1, 2009

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