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A numerical method is presented for determining flow rates in centrifugal isotope separation cascades that satisfy the required “ideal cascade” conditions. This method is an iterative method, which in the iteration process uses the q-iteration method to give the concentration and distributions of components under a specified hydraulic status for a cascade; and then, based on the concentration distributions, solves the algebraic equations describing the hydraulic status of the cascade to improve the specified hydraulic status towards the required “ideal cascade” conditions. The material losses in the cascade pipes and centrifuges are taken into account. Numerical simulations are performed by taking an MARC cascade with variant stage separation factors as an example. The results from four cases with and without material losses are compared. The results demonstrate that the method works very well, and show that when the material losses are nonexistent or very small, the concentration distributions can exactly satisfy the “ideal cascade” condition; but when the material losses are large, the “ideal cascade” condition can not be satisfied, but the method can produce a solution that allows the condition to be approximately satisfied.