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Aqueous Hydrotropic Solution as an Efficient Solubilizing Agent for Andrographolide from Andrographis paniculata Leaves

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Abstract:

An aqueous solution based extraction process for andrographolide from Andrographis paniculata leaves has been developed using alkyl benzene sulfonates and carboxylates as hydrotropes. The plant cells are permeabilized by the hydrotrope solutions followed by solubilization of andrographolide into the solutions. The extraction and solubilization of andrographolide is affected by structure and concentration of hydrotrope, temperature and particle size. Sodium cumene sulfonate (Na‐CS) shows the most efficient solubilization of andrographolide amongst the hydrotropes studied. The solubility of andrographolide increased by two orders of magnitude in Na‐CS aqueous solutions and ∼96% andrographolide extraction was achieved in just 20┬ámin.

Keywords: Andrographis paniculata; Andrographolide; extraction; hydrotropy; sodium cumene sulfonate; sodium salicylate

Document Type: Research Article

DOI: http://dx.doi.org/10.1080/01496390600633675

Affiliations: Institute of Chemical Technology, University of Mumbai, Mumbai, India

Publication date: January 1, 2006

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