Sclerosing pancreatitis presenting as a periampullary tumour

Authors: AK Sahajpal; CM Vollmer; A Pollett; S Gallinger

Source: Hpb, Volume 5, Number 4, November 2003 , pp. 268-272(5)

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Abstract:

Background Sclerosing lesions of the pancreatic duct are rare and may be secondary to primary sclerosing cholangitis (PSC) or the result of a primary sclerosing process (the recently described lymphoplasmacystic sclerosing pancreatitis, LSP). Occasionally this process may present as a mass lesion.

Case outline A 21-year-old man presented with abdominal pain and jaundice, giving a high index of suspicion for a periampullary malignancy. There were minimal symptoms suggestive of PSC. The resected head of the pancreas demonstrated changes of chronic pancreatitis with a fibro-inflammatory process of the pancreatic duct suggesting an underlying ductal sclerosing process.

Discussion Clinical presentation and imaging characteristics of PSC involving the pancreas are often misleading and may suggest a neoplasm as the underlying disorder. Conclusive diagnosis is usually not determined until after surgical intervention. Although racial differences in pancreatic duct involvement have been suggested, the underlying histopathology is the same as in PSC involving the biliary ducts.

Keywords: primary sclerosing cholangitis; pancreatic duct; periampullary pseudomalignancy; sclerosing pancreatitis

Document Type: Research article

DOI: http://dx.doi.org/10.1080/13651820310015761

Publication date: 2003-11-01

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