Home >> Toxicological and Environmental Chemistry, Volume 91, Number 4

Genetic profile of overweight and obese school-age children

Authors: Torres-Bugarin, Olivia1; Fernandez-Garcia, Alicia2; Torres-Mendoza, Blanca3; Zavala-Aguirre, Jose4; Nava-Zavala, Arnulfo1; Zamora-Perez, Ana5

Source: Toxicological and Environmental Chemistry, Volume 91, Number 4, June 2009 , pp. 789-795(7)

Publisher: Taylor and Francis Ltd

Buy & download fulltext article:

OR

Price: $56.94 plus tax (Refund Policy)

Abstract:

Obesity is associated with overproduction of free radicals that promotes genotoxicity and could be measured as micronuclei (MN) and nuclear abnormalities (NA) in buccal mucosa cells. The frequency of MN and NA in buccal mucosa cells from overweight and obesity school-age children was determined. In a cross-sectional study, four anthropometric parameters were obtained from each child and one buccal mucosa sample was collected from each child. The slides were stained with orcein and fast green and microscopically analyzed for MN and NA. Twenty overweight and obesity school-age children (7-11 years old) from three schools located at the metropolitan area of Guadalajara were selected to form three groups with 20 children each, according to the weight features as follows: (1) normal weight; (2) overweight; and (3) obesity. No marked differences were found between groups for frequency of MN and NA. Genotoxicity, as indicated by increase in binucleated (BN) cells, was found in children within both overweight and obese groups exposed to passive tobacco smoke. There was no evidence of genetic instability in overweight and obese school-age children and no associations between body weight and genotoxicity markers found.

Keywords: overweight; obesity; children; genetic instability; micronucleated cell; nuclear abnormalities

Document Type: Research article

DOI: http://dx.doi.org/10.1080/02772240802404966

Affiliations: 1: Departmento de Morfologia, Programa Internocional, Facultad de Medicina, Departamento de Investigacion, Programa Internacional, Universidad Autonoma de Guadalajara, Zapopan, Jalisco, Mexico 2: Maestria en Nutricion Clinica, Universidad del Valle de Atemajac, Guadalajara, Jalisco, Mexico 3: Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara y Universidad del Valle de Atemajac, Guadalajara, Jalisco, Mexico 4: Escuela de Biologia, Universidad Autonoma de Guadalajara, Guadalajara, Jalisco, Mexico 5: Instituto de Investigacion en Odontologia, Division de Disciplinas Clinicas, Departamento de Clinicas Odontologicas Integrales, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico

Publication date: 2009-06-01

Marked list

Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
^ Back to top
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page