Evaluation of the antimutagenic and antiradical potentials of extracts from the tubers of (Tunisian) Cyperus rotundus

Authors: Kilani, Soumaya¹; Bouhlel, Inès¹; Ben, Ribai¹; Abdelwahed, Afef¹; Hayder, Nawel¹; Mahmoud, Amor²; Ghedira, Kamel²; Chekir-Ghedira, Leila¹

Source: Toxicological and Environmental Chemistry, Volume 87, Number 3, July-September 2005 , pp. 415-425(11)

Publisher: Taylor and Francis Ltd

Abstract:

The mutagenic potential of aqueous, total oligomers flavonoids (TOF), ethyl acetate and methanol extracts from tubers of Cyperus rotundus L. was assessed using Ames Salmonella tester strains TA98 and TA100, and SOS chromotest strain Escherichia coli PQ37 with and without metabolic activation (S9). None of the different extracts produced a mutagenic effect. Likewise, the antimutagenicity of the same extracts was tested using the “Ames test” and the “SOS chromotest”. Our results showed that C. rotundus extracts possess antimutagenic effects against S. typhimurium TA98 and TA100 strains towards the mutagen aflatoxin B1 (AFB1), similar to E. coli PQ37 strain against AFB1 and Nifuroxazide mutagens using the SOS chromotest assay. A free radical scavenging test was used in order to explore the antioxidant capacity of the extracts obtained from the tubers of C. rotundus . TOF, ethyl acetate and methanol extracts showed an important free radical scavenging activity towards the 1,1-diphenyl-2-picrylhydrazine (DPPH) free radical. These extracts showed an IC50 value of respectively 5, 20 and 65?µg?mL -1 . The beneficial effects of TOF, ethyl acetate and methanol extracts of C. rotundus were assessed by antioxidant and antimutagenic activities.

Keywords: Cyperus rotundus tubers; mutagenicity; antimutagenicity; SOS chromotest; Ames test; free radical scavenging activity

Document Type: Research article

DOI: http://dx.doi.org/10.1080/02772240500286194

Affiliations: 1: Faculty of Dental Medicine, Department of Molecular and Cellular Biology, Rue Avicenne Monastir 5000, Tunisie 2: Faculty of Pharmacy, Department of Pharmacognosy, Rue Avicenne Monastir, 5000, Tunisie

Publication date: 2005-07-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Chemistry (General) ,  Earth and Environmental Sciences ,  Toxicology
• By this author: Kilani, Soumaya ;  Bouhlel, Inès ;  Ben, Ribai ;  Abdelwahed, Afef ;  Hayder, Nawel ;  Mahmoud, Amor ;  Ghedira, Kamel ;  Chekir-Ghedira, Leila

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers