Effect of Fenvalerate Exposure on Erythrocyte Antioxidant Status in Protein Malnourished Rats

Authors: Sandhir R.; Parwani S.; Kiran R.

Source: Toxicological and Environmental Chemistry, Volume 83, Numbers 1-4, Numbers 1-4/2002 , pp. 99-106(8)

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Abstract:

Oral administration of fenvalerate at a dose of 30 mg/kg body weight, for 15 days, to female rats maintained on low protein diet resulted in significant decrease in number of erythrocytes compared to the rats on normal protein diet. Animals on low protein diet had greater decrease in glutathione content compared to rats on normal protein following fenvalerate treatment. The decrease in glutathione levels was accompanied with decrease in the activities of glucose-6-phosphate dehydrogenase and glutathione reductase. There was a significant increase in the activity of glutathione-S-transferase after fenvalerate treatment. However, this increase was more pronounced in animals on low protein diet. The phospholipid to protein ratio was also reduced in the animals on low protein diet following fenvalerate treatment. The results obtained from the present study suggest that low protein diet enhances the vulnerability of erythrocytes to fenvalerate.

Keywords: Pyrethroids; Fenvalerate; Protein deficiency; Erythrocytes; Glutathione; Antioxidant enzymes

Document Type: Research article

Affiliations: 1: Department of Biochemistry, Panjab University, Chandigarh 160 014, India

Publication date: 2002-01-01