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Home / Phosphorus, Sulfur, and Silicon and the Related Elements, Volume 187, Number 5

Facile Synthesis of 1,5-Benzothiazepines in Water Using Tetrabutylammonium Tribromide

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A simple, environmentally benign, and efficient method was developed for the preparation of 1,5-benzothiazepines via a one-pot condensation reaction of 2-aminothiophenol with 1,3-diaryl- 2-propenones using tetrabutylammonium tribromide as an efficient and versatile catalyst in water.

Keywords: 1,3-diaryl-2-propenones; 1,5-Benzothiazepines; 2-aminothiophenol; tetrabutylammonium tribromide

Document Type: Research Article

Affiliations: 1: School of Basic Medicine,Xinxiang Medical University, Xinxiang,Henan, China 2: College of Chemistry and Chemical Engineering,Xinxiang University, Xinxiang,Henan, China 3: School of Pharmacy,Xinxiang Medical University, Xinxiang,Henan, China

Publication date: 01 May 2012

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