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Trimethylsilyl Protection of Alcohols Over Phosphorus Pentoxide Supported on Silica Gel

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An eco-friendly and mild protocol for trimethylsilyl protection of alcohols over phosphorus pentoxide supported on silica gel using hexamethyldisilazane has been described. Solvent-free and ambient reaction conditions, easy workup, short reaction times, excellent yields, and reusability of the catalyst are the noticeable features of this methodology.

GRAPHICAL ABSTRACT

Keywords: Alcohols; P2O5/SiO2; hexamethyldisilazane; trimethylsilylation

Document Type: Research Article

Affiliations: Department of Chemistry, Faculty of Sciences,University of Sistan and Baluchestan, Zahedan, Iran

Publication date: 01 July 2011

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