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Synthesis of Some Novel 5-(Arylidene)-2-imino-3(pyridin-2-yl)thiazolidin-4-one Derivatives

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Treatment of 2-aminopyridine (1) with chloroacetyl chloride in dry benzene gave 2-chloro-N-(pyridin-2-yl)acetamide (3), which on further reaction with potassium thiocyanate gave 2-imino-3-(pyridin-2-yl)thiazolidin-4-one (4) as an intermediate compound for the synthesis of pyridin-2-yl substituted 2-imino-thiazolidine-4-one derivatives. Cyclocondensation reaction of (4) with a series of aromatic aldehydes gave 5-arylidene derivatives of pyridin-2-yl substituted 2-imino-thiazolidine-4-ones 5a-j. 1H and 13C NMR spectroscopy, as well as elemental analyses, were used for the identification of these new compounds.

Keywords: Benzylidene; pyridine; thiazolidin-4-one

Document Type: Research Article


Affiliations: Chemistry Department, Arak University, Arak, Iran

Publication date: 2009-07-01

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