Synthesis, Structure, and In Vitro Anti-HIV Activity of New Pyrazole, 1,2,4-Thiadiazole, and 1,2,4-Triazole Derivatives

Author: Al-Soud, Y. A.

Source: Phosphorus, Sulfur, and Silicon and the Related Elements, Volume 183, Number 10, October 2008 , pp. 2621-2636(16)

Publisher: Taylor and Francis Ltd

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Abstract:

α,α'-Dichloroazo compounds 6 react with Lewis acid to furnish 1-(chloroalkyl)-1-aza-2-azoniaallene salts 4. The cations 4 react with acetylenes, isothiocyanates, isocyanates, and carbodiimides under [3+2]-cycloaddition. The cycloadducts undergo consecutive reactions, e.g., [1,2]-shifts of alkyl groups. The newly synthesized products were evaluated for their anti-HIV-1 and anti-HIV-2 activity in MT-4 cells.

Keywords: 1,2,4-Thiadiazolse; 1,2,4-Triazole; NNRTIs; pyrazoles; synthesis

Document Type: Research article

DOI: http://dx.doi.org/10.1080/10426500801968003

Affiliations: 1: Department of Chemistry, College of Science, University of Al-al-Bayt, Al-Mafraq, Jordan

Publication date: 2008-10-01